| Designation |
Principle Investigator |
Title / Scope of Project |
Nature of Project |
Grant name,
Awarding organisation |
| Senior Consultant |
Adrian Low Fatt Hoe |
Coronary microcirculation hemodynamics and its relation to myocardial viability and remodeling (Genetics of AMI) |
Research |
National University of Singapore (NUS) |
| Senior Consultant |
Adrian Low Fatt Hoe |
Predictors of rapid progression of coronary atherosclerotic plaque |
Research |
|
| Senior Consultant |
Adrian Low Fatt Hoe |
Biolimus Eluting A-9 Stent Obviating Luminal Narrowing |
Trial |
Biosensors International Group |
| Senior Consultant |
Adrian Low Fatt Hoe |
e-Select Registry: A Multi-center Post-market Surveillance of Cypher Select Sirolimus eluting stent |
Trial |
Cordis Europa |
| Senior Consultant |
Chai Ping |
Assessment of left ventricular hypertrophy and myocardial fibrosis in hypertensive heart disease using cardiovascular magnetic resonance imaging |
Research |
National Medical Research Council (NMRC) |
| Senior Consultant |
Chai Ping |
Evaluation of the NHG Heart Failure Disease Management Programme @ NUH |
Research |
|
| Senior Consultant |
Chai Ping |
Multi-Slice Computed Tomography for Detecting and Quantitating Thoracic Aortic Atheromas: Comparison with Transoesophageal Echocardiography and Prediction of Neurocognitive Dysfunction after Coronary Artery Bypass Surgery |
Research |
National Medical Research Council (NMRC) |
| Senior Consultant |
Chai Ping |
Double-blind, placebo-controlled, multicenter Acute Study of Clinical Effectiveness of Nesiritide in subjects with Decompensated Heart Failure |
Trial |
Janssen-Cilag |
| Senior Consultant |
James Yip |
EARLY – Bosentan-use in NYHA 2 pulmonary arterial hypertension patients |
Research |
|
| Senior Consultant |
James Yip |
Tadalafil in pulmonary arterial hypertension patients |
Research |
Singapore Heart Foundation (SHF) |
| Senior Consultant |
James Yip |
Long-term extension, multi-centre, multi-national study to evaluate the safety and tolerability of oral BAY 63-2521 (1 mg, 1.5 mg, 2 mg, or 2.5 mg tid) in patients with symptomatic Pulmonary Arterial Hypertension (PAH) |
Trial |
Bayer Healthcare AG |
| Senior Consultant |
James Yip |
SERAPHIN: Study with ERA in Pulmonary Hypertension to Improve clinical outcome. A multicentre, double-blinded, randomized, placebo-controlled, parallel group, event-driven Phase III study to assess the effects of ACT-064992 on morbidity and mortality in... |
Trial |
Actelion |
| Senior Consultant |
James Yip |
Randomized, double-blind, placebo-controlled, multi-center, multi-national study to evaluate the efficacy and safety of oral BAY 63 2521 (1 mg, 1.5 mg, 2 mg, or 2.5 mg TID) in patients with symptomatic Pulmonary Arterial Hypertension (PAH) |
Trial |
Bayer Schering |
| Senior Consultant |
Ling Lieng Hsi
(Co-Principle Investigator) |
Genetics of Atrial Fibrillation |
Research |
Start Up Grant (NUS) |
| Senior Consultant |
Ling Lieng Hsi
|
Identification of novel genetic determinants of atrial fibrillation in an asian population |
Research |
National Medical Research Council (NMRC) |
| Senior Consultant |
Tan Huay Cheem |
Asian DIOR Registry (A multicentre registry with paclitaxel-elutingCoronary balloon to prevent restenosis) |
Research |
Unnamed pharmaceutical company |
| Senior Consultant |
Tan Huay Cheem |
CAT VI RCT (A multicentre randomised controlled trial of Boomerang Catalyst VI System-Assisted Manual Compression vs manual compression alone for the management of the femoral arteriotomy after percutaneous intravascular procedures)
|
Research |
Unnamed pharmaceutical company |
| Senior Consultant |
Tan Huay Cheem |
Comparison of N-acetylcysteine vs sodium bicarbonate vs placebo in reducing contrast induced nephropathy (CONTRAST) |
Research |
CTERU Small Grant |
| Senior Consultant |
Tan Huay Cheem |
REMEDEE (Prospective randomized study to evaluate the safety and efficacy of an abluminal sirolimus-coated bioengineered stent (Combo bioengineered sirolimus eluting stent) compared with a Taxus Liberte stent control arm for treatment of stenotic lesions in native coronary arteries) |
Research |
Unnamed pharmaceutical company |
| Senior Consultant |
Tan Huay Cheem |
TRACER (Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome)
|
Research |
Schering-Plough Research Institute |
| Senior Consultant |
Tan Huay Cheem |
Use of endothelial progenitor cell capture stent in patients with acute ST-segment myocardial infarction undergoing primary percutaneous coronary intervention |
Research |
|
| Senior Consultant |
Tan Huay Cheem |
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of SCH 530348 in Addition to Standard of Care in Subjects With Acute Coronary Syndrome: Thrombin Receptor Antagonist for Clinical Event Reduction in Acut |
Trial |
Schering-Plough Research Institute |
| Senior Consultant |
Tan Huay Cheem |
A Prospective, Evaluation in a Randomized Trial of the Safety and Efficacy of the Use of the TAXUS ® Element ™ Paclitaxel-Eluting Coronary Stent System for the Treatment of De Novo Coronary Artery Lesions |
Trial |
Boston Scientific Corporation |
| Senior Consultant |
Tan Huay Cheem |
A Prospective Multi-Center Trial to assess an Everolimus-Eluting Coronary Stent System (PROMUS ™ Element ™ ) |
Trial |
Boston Scientific Corporation |
| Senior Consultant |
Tan Huay Cheem |
A Prospective, Randomized, Multicenter Study to evaluate the safety, efficacy and performance of the CardioMind Coronary Stent Systems for treatment of STENOTIC lesions in small diameter native coronary arterties |
Trial |
CardioMind |
| Senior Consultant |
Tan Huay Cheem |
AntiCD 34 Antibody coated stent Genous in STEMI: angiographic follow-up |
Trial |
OrbusNeich Medical Co |
| Senior Consultant |
Tan Huay Cheem |
Randomized, multinational, double-blind study, comparing high loading dose regimen of clopidogrel versus standard dose in Patients with unstable angina or non-ST segment elevation myocardial infarction managed with an early invasive strategy |
Trial |
Sanofi Aventis Singapore Pte Ltd |
| Senior Consultant |
Yeo Tiong Cheng |
Adverse left ventricular (LV) remodelling in chronic right ventricular (RV) pacing |
Research |
|
| Consultant |
Lee Chi-Hang, Ronald |
Adiponectin and coronay plaque vulnerability patients undergoing non-urgent percutaneous coronary intevention: An virtual histology- intravescular ultrasound study |
Research |
National University of Singapore (NUS) |
| Consultant |
Lee Chi-Hang, Ronald |
Bridging fund for Lee Chi Hang Ronald |
Research |
Yoo Loo Lin School of Medicine (YLLSoM) |
| Consultant |
Poh Kian Keong |
Combination of Aortic Valve Calcium by Multislice Detector Computed Tomography and Serum pro-BNP levels as Prognostic Indicators of Incremental value in Patients with Aortic Stenosis |
Research |
Singapore Heart Foundation (SHF) |
| Consultant |
Poh Kian Keong |
Effects of Stem cells and Myoblasts on Diabetic Cardiomyopathy in Small Animals |
Research |
|
| Consultant |
Poh Kian Keong |
Relations of Left Ventricular Geometry and Myocardial Perfusion to Ischemic Mitral Regurgitation |
Research |
|
| Consultant |
Poh Kian Keong |
The Use of Left Ventricular Vortex Formation Index in Heart Failure |
Research |
|
| Consultant |
Seow Swee Chong |
Genetics of Brugada syndrome and Sudden cardiac death |
Research |
|
| Consultant |
Seow Swee Chong |
Microvolt T wave alternans for risk stratification for sudden death |
Research |
|
| Consultant |
Seow Swee Chong |
Mobile phone based ambulatory ECG monitoring |
Research |
|
| Consultant |
Seow Swee Chong |
OPTIMIZE trial - cardiac resynchronization optimization using electrical activation time vs echocardiography |
Research |
|
| Consultant |
Teo Swee Guan |
e-Healing (Healthy Endothelilal Accelerated Lining inhibits Neointimal Growth), Genous Bio-engineered R Stent, Post Marketing Registry |
Trial |
OrbusNeich Medical Co |
| Consultant |
Teo Swee Guan |
Patient related outcomes with Endeavor versus Cypher stenting Trial (PROTECT) |
Trial |
Medtronic Bakken |
| Consultant |
Wong Ching Chiew Raymond |
A multicenter, randomized, double, parallel group, placebo-controlled study to evaluate the 6 months efficacy and safety of aliskiren therapy on top of standard therapy, on morbidity and mortality when initiated early after hospitalization for acute decompensated heart failure |
Research |
|
| Consultant |
Wong Ching Chiew Raymond
(Co-Principle Investigator) |
A randomised, double-blinded, 2-way crossover, placebo-controlled study to investigate the influence of a single dose of Moxifloxacin ont eh QTc interval in healthy male and female subjects for positive control validation in selected denters of the PATIENT-1 trial |
|
|
| Consultant |
Wong Ching Chiew Raymond |
A twelve-week, randomized, double-blind, multi-center, parallel group, active controlled study to evaluate the efficacy, safety and tolerability of LCZ696 compared to valsartan in patients with chronic heart failure and preserved left-ventricular ejection fraction |
Research |
|
| Consultant |
Wong Ching Chiew Raymond |
Adverse Left Ventricular Remodeling in Patients with Chronic Right Ventricular |
Research |
|
| Consultant |
Wong Ching Chiew Raymond |
Functional assessment of anthracycline-cardiomyopathy using N-terminal pro-brain natriuretic peptide and myocardial strain rate imaging |
Research |
Singapore Heart Foundation (SHF) |
| Consultant |
Wong Ching Chiew Raymond
(Study team member) |
Questionnaire survey of sleep-related breathing disorder in heart failure: Prevalence in systolic and diastolic failure and relation to medium-term outcome |
Research |
|
| Consultant |
Wong Ching Chiew Raymond |
A multicenter, randomized, double-blind, parallel group, placebo-controlled study to evaluate the 6 months efficacy and safety of aliskiren therapy on top of standard therapy, on morbidity and mortality when initiated early after hospitalization for acute |
Trial |
Novartis (Singapore) Pte Ltd |
| Consultant |
Wong Ching Chiew Raymond |
A twelve-week, randomized, double-blind, multi-center, parallel group, active controlled study to evaluate the efficacy, safety and tolerability of LCZ696 compared to valsartan in patients with chronic heart failure and preserved left-ventricular ejection |
Trial |
Novartis (Singapore) Pte Ltd |
| Associate Consultant |
Carolyn Lam |
Canine study of the Cardiorenal Syndrome: Renal Effects of Isolating the Renal Venous System from Severe Tricuspid Regurgitation in Heart Failure by Percutaneous Insertion of an Inferior Vena Cava Valve (Laboratory-based work using a large animal model of heart failure) |
Research |
|
| Associate Consultant |
Carolyn Lam |
Cardiac Geometry, Systolic Ventricular-Vascular Coupling and Diastolic Function in Heart Failure with Normal Ejection Fraction (Human echocardiographic study) |
Research |
|
| Associate Consultant |
Carolyn Lam
(Co-Principle Investigator) |
Clinical Trials in Heart Failure |
Research |
National Institutes of Health (NIH, United States) |
| Associate Consultant |
Carolyn Lam |
Diuretic Optimization Strategies Evaluation in Acute Heart Failure (DOSE-AHF trial): Prospective randomized controlled trial of Furosemide continuous infusion versus bolus dosing in acute heart failure |
Research |
|
| Associate Consultant |
Carolyn Lam |
Genetic Epidemiology of Heart Failure/ Ventricular-Vascular Structure & Function |
Research |
|
| Associate Consultant |
Carolyn Lam |
Heart Failure with Preserved Ejection Fraction: Pathophysiology |
Research |
|
| Associate Consultant |
Carolyn Lam |
Left- and right-sided hemodynamics, Cardiac Geometry, Vascular-Ventricular Coupling, Exercise Hemodynamics, Cardiorenal Physiology (Population-based clinical studies in humans contributing towards a Master’s degree in Clinical and Translational Science) |
Research |
|
| Associate Consultant |
Carolyn Lam |
Murine Model of Experimental Hypertensive Heart Disease Role of the Natriuretic Peptide System and Cardiomyocyte Biology (Laboratory-based work using a small animal model of heart failure) |
Research |
|
| Associate Consultant |
Carolyn Lam |
New Biomarkers in Left Ventricular Dysfunction and Heart Failure (Industry supported study) |
Research |
|
| Associate Consultant |
Carolyn Lam |
Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart Failure (RELAX trial): Prospective randomized placebo-controlled trial of Sildenafil in Heart Failure with Preserved Ejection Fraction |
Research |
|
| Associate Consultant |
Carolyn Lam |
Protocol for the Cardiorenal Rescue Study in Acute Decompensated Heart Failure (CARRESS-HF trial): Prospective randomized controlled trial of ultrafiltration versus usual care in cardiorenal syndrome
|
Research |
|
| Associate Consultant |
Carolyn Lam |
Renal Optimization Strategies Evaluation in Acute Heart Failure (ROSE-AHF) |
Research |
|
| Associate Consultant |
Carolyn Lam |
Study of the Natriuretic Peptide System and cardiomyocyte Biology in a Murine Model of Hypertension (Bench/Basic Science study) |
Research |
|
| Associate Consultant |
Carolyn Lam |
Surgery Versus Medical Treatment Alone for Patients with Significant Mitral Regurgitation and Non-Ischemic Congestive Heart Failure (SMMART-HF): Prospective randomized controlled trial of surgical mitral valve repair in non-ischemic dilated cardiomyopathy with secondary mitral regurgitation |
Research |
|
| Associate Consultant |
Carolyn Lam |
The Effects of Sildenafil on Cardiovascular Reserve Function in Heart Failure with Preserved Ejection Fraction (Stress-RELAX Study) |
Research |
|
