Heart valves are 'doors' that control the flow of blood between the different chambers or parts of the heart.
In valvular heart disease, one or more of the heart valves becomes damaged and loses its function.
In general, valves can lose its ability to close tightly and loses its role to control blood flow in one direction. The result of this disease is that backward flow occurs. The heart function loses its effectiveness.
The heart valve can also become “tight” thereby narrowing the space through which the blood can flow forward. There can also be a mixture of both. In summary, two abnormal processes can occur:
This reduces the heart's ability to pump blood to the rest of the body. (An example is mitral valve regurgitation or aortic valve regurgitation).
You could visit your family doctor who will take a detailed history, do a thorough physical examination and order the necessary tests. Your doctor may refer you to a cardiologist for further evaluation. The cardiologist may do an echocardiogram, a painless test using ultrasound, to help him look at your heart and its different structures.
This will help your doctor to understand your condition and be able to make an accurate diagnosis and give the correct treatment.
Patients will start experiencing symptoms at different ages depending on the disease that they have. This can range from the very young to the very old.
In the early stage, you may have no symptoms and feel alright even if your valve is badly damaged. The symptoms may appear later and become progressively worse.
Common symptoms include:
Depending on what is found, you may be:
Your heart valve specialist team (Surgeon/Cardiologist) will:
There are four valves in your heart made of thin and strong flaps of tissue that open and close as your heart pumps to make sure that blood flows in the right direction through your heart. However, valve problems may occur either because of a birth defect, or ageing, or even from certain diseases.
Your damaged valves can either be repaired or replaced through a Heart Valve Surgery.
Your surgeon will always try to save as much of your valve as possible unless this affects the result of the surgery. If the repair fails, he will replace the valve at the same operation.
Valves can be replaced by:
There are a few methods for Heart Valve Surgery:
Before the surgery:
On the day of the surgery:
After the surgery:
Complications are not common, but some can be serious.
Transcatheter Aortic Valve Implantation (TAVI) is used to treat severe Aortic Stenosis, a condition in which the aortic valve becomes narrowed, obstructing the outflow of blood from the heart and thereby requiring the heart to work harder to pump blood around the body.
TAVI is a procedure performed using the Edwards Sapien Transcatheter Heart Valve (THV), an artificial heart valve designed to be inserted into your heart so that it holds open and replaces your diseased aortic valve. It consists of a metal stent (made of steel or cobalt-chromium) which secures the device in its intended position inside your own valve, and valve leaflets (made of biological material derived from cows) to direct the flow of blood out of your heart.
TAVI now offers effective treatment to patients who are at high risk for conventional open heart surgery. It is also intended to prevent further damage to the heart from Aortic Stenosis and to prolong life, which medical therapy cannot do.
Before the procedure, you will undergo routine investigations to evaluate whether TAVI is possible and which of the two techniques for TAVI (Transfemoral or Transapical route) is most appropriate for you. The investigations will also identify any other considerations that need to be addressed for your treatment.
The investigations include:
Whether you are selected to undergo the transfemoral or the transapical approach, this procedure will be performed under general anesthesia. As the heart is not opened to expose the aortic valve, fluoroscopy (X-rays) and transesophageal echocardiography (ultrasound) are used to visualise the heart and THV, and to guide the insertion of the THV. The duration of X-ray exposure that you will receive will normally be less than 30 minutes, the normal length of time it takes for a coronary artery procedure in the cardiac catheterisation laboratory.
2.3.1. Transfemoral TAVI
The transfemoral device is designed to be implanted through the blood vessel (femoral artery) in your leg. Due to the size of the catheter (hollow tube) being placed in your artery for this approach, your doctors will evaluate the angiograms and/or CT scans to ensure that your blood vessels are big enough for this device. Prior to implantation, the THV is “crimped” (carefully compressed to a size that fits inside your femoral artery) using a specifically designed crimping device. The crimped THV is mounted onto a balloon delivery catheter, a special device used to carry the THV up to the heart and directly into your aortic valve. The valve is then expanded using a balloon to fit inside your stenotic aortic valve, holding your own valve open permanently. Once the valve is in position and the delivery system is removed from your femoral artery, the artery is closed using a special suture device designed for this purpose. After the procedure, you will be transferred to the Coronary Care Unit (CCU).
2.3.2. Transapical TAVI
The transapical approach is used for patients whose arteries are too small or too diseased for the transfemoral approach.
The delivery system for this approach is designed for THV implantation through the tip (apex) of your heart, which is reached through a small incision made between the ribs just below the left nipple. The crimped THV and delivery system is inserted through the apex of your heart directly into your stenotic aortic valve. The valve is then expanded using a balloon to fit across your stenotic aortic valve, holding it open permanently. After the procedure, you will be transferred to the Cardiothoracic Intensive Care Unit (CTICU).
After the TAVI procedure, you will be transferred to either the CCU ward or the CTICU ward for close monitoring. When you are first transferred, you may be under sedation and on ventilatory support. Over the course of the next 24 hours, you will be awakened from the sedation and allowed to breathe on your own with the ventilation tube removed. You will remain in the CCU or CTICU ward until your doctor feels that you can be transferred to a regular hospital ward, where you will continue to be monitored until your discharge from the hospital, usually within 5 – 7 days.
You will be given blood thinning medications such as aspirin and clopidogrel (Plavix). You should continue taking these or other blood thinners for 6 months after the procedure and aspirin for life (as recommended for routine stenting of coronary blood vessels and any replacement heart valve). The following routine checks will be completed while you are in hospital:
Thereafter, you will be required to see your doctor in the clinic after 30 days, 6 months, 12 months, and then once a year. The routine checks such as echocardiography are repeated at your first and subsequent outpatient follow-ups.
Like any other operations, there are risks associated with this procedure. However, the long-term risk to your life and your quality of life may be higher if severe Aortic Stenosis is not treated.
The risks of TAVI include the following:
The mitral valve is located between the two chambers on the left side of the heart which directs blood flow in one direction - from the upper chamber (left atrium) to the lower chamber (left ventricle). When this valve does not close completely, mitral valve regurgitation or backflow of blood in the left ventricle occurs. In severe cases, reduced blood flow is pumped out of the heart. This creates excessive workload on the heart leading to dilation of the heart chambers. If left untreated, it can result in heart failure.
There are currently several options of treatment available for mitral valve regurgitation. These include medical treatment, surgery, or less invasive valve repair such as the mitraclip therapy.
Some investigations would need to be performed before the procedure. These include but are not limited to a transthoracic and transesophageal echocardiogram (ultrasound test for the heart). These two tests will allow for more accurate assessment of the mitral valve to determine if mitraclip therapy is suitable. Other tests such as coronary angiograms, electrocardiograms, chest X-rays and blood tests may also be needed prior to the procedure.
The mitraclip therapy procedure is done under general anesthesia and takes approximately 3 to 4 hours. A catheter (long thin flexible tube) is guided through the femoral (leg) vein to reach the heart. The clip is delivered through the catheter to the region of the mitral valve. Upon reaching the mitral valve, it clips the mitral valve to allow it to close better. The clip is left on the mitral valve while the rest of the delivery system and the catheter are removed.
After mitraclip therapy procedure, you will be transferred to the cardiac monitoring unit for a day. After this, your cardiologist would review you and may transfer you to the regular hospital ward for the next two days before discharge. Additional tests would be performed after the mitraclip therapy procedure. These include a repeat transthoracic echocardiogram, blood tests and a chest X-ray. You may also be given blood thinners such as aspirin and or clopidogrel for six months.